Open C Tuning (CGCGCE) is one of the most used alternate guitar tunings. It is used by many great bands, like Led Zeppelin and Soundgarden. C-major chord sounds very rich and powerful in this tuning (try it: strike all the strings without any fretting). Here is one riff in that tune, that is played with guitar slide:
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Open C Tuning
Guitar tuning can be easily changed and customized according to your needs. It’s not a bad idea to try some alternate guitar tuning, because you will play differently and you will easily get lot of new ideas.